HYDROXY ITRACONAZOLE
HYDROXY ITRACONAZOLE(HYDROXY ITRACONAZOLE)
CAS: 112559-91-8
化学式: C35H38Cl2N8O5
| 中文名 | HYDROXY ITRACONAZOLE |
| 英文名 | HYDROXY ITRACONAZOLE |
| 别名 | 羟基伊曲康唑 依曲康唑杂质 伊曲康唑杂质8 伊曲康唑杂质1 伊曲康唑代谢物 伊曲康唑2-羟基代谢物 羟基伊曲康唑(伊曲康唑代谢物) |
| 英文别名 | R 63373 HYDROXY ITRACONAZOLE Itraconazole 2-Hydroxy Metabolite Itraconazole metabolite Hydroxy Itraconazole Itraconazole Impurity 8(Hydroxy Itraconazole) 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-Methylpropyl)- 3H-1,2,4-Triazol-3-one, 4-4-4-4-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)- 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one |
| CAS | 112559-91-8 |
| 化学式 | C35H38Cl2N8O5 |
| 分子量 | 721.63 |
| 密度 | 1.44±0.1 g/cm3(Predicted) |
| 熔点 | 76-78°C |
| 沸点 | 884.7±75.0 °C(Predicted) |
| 溶解度 | 氯仿 (微溶) 、乙酸乙酯 (微溶) 、甲醇 (微溶) |
| 酸度系数 | 14.72±0.20(Predicted) |
| 存储条件 | -20°C Freezer |
| 外观 | 固体 |
| 颜色 | White to Pale Beige |
| 体外研究 | Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ). Although Hydroxy Itraconazole is also reported to have antifungal activity in vitro, its pharmacokinetics in humans has been studied less than that of ITZ. ITZ and Hydroxy Itraconazole have a triazole ring and inhibit CYP3A. Their half-lives can be extended by 26-60% with repeated administration compared to single administration. |
| 体内研究 | The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view. |
HYDROXY ITRACONAZOLE - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.413 ml | 7.066 ml | 14.131 ml |
| 5 mM | 0.283 ml | 1.413 ml | 2.826 ml |
| 10 mM | 0.141 ml | 0.707 ml | 1.413 ml |
| 5 mM | 0.028 ml | 0.141 ml | 0.283 ml |
最后更新：2024-01-02 23:10:35
供应商列表
现货供应
产品名: Hydroxy Itraconazole 去供应商网站查看 询盘CAS: 112559-91-8
产地: 上海
规格: H884483
价格: 1mg-2157,5mg-8734
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
现货供应
产品名: HYDROXY ITRACONAZOLE 去供应商网站查看 询盘CAS: 112559-91-8
产地: 上海
规格: 98%
价格: 1mg 2000,5mg 6000
库存: 现货
电话: 18301782025
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QQ: 3008007403
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产品描述: HYDROXY ITRACONAZOLE 98% MedMol 货号：S80107
现货供应
产品名: Hydroxy Itraconazole 去供应商网站查看 询盘CAS: 112559-91-8
产地: 上海
规格: H884483
价格: 1mg-2157,5mg-8734
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
现货供应
产品名: HYDROXY ITRACONAZOLE 去供应商网站查看 询盘CAS: 112559-91-8
产地: 上海
规格: 98%
价格: 1mg 2000,5mg 6000
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: HYDROXY ITRACONAZOLE 98% MedMol 货号：S80107
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